患有充血性心力衰竭的终身风险:弗雷明汉心脏研究
Donald M Lloyd-Jones1, Martin G Larson, Eric P Leip
1National Heart, Lung, and Blood Institute's Framingham Heart Study, National Institutes of Health, Framingham, MA 01702, USA. don@fram.nhlbi.nih.gov
Circulation
|December 11, 2002
概括
患上充血性心力衰竭 (CHF) 的终身风险为男性和女性的五分之一. 高血压显著增加这种风险,强调需要控制血压.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 充血性心力衰竭 (CHF) 是一个日益严重的公共卫生问题,导致严重的发病率和死亡率.
- 了解发展CHF的终身风险对于有效的公共卫生战略和资源配置至关重要.
研究的目的:
- 为了确定在不同年龄段发展明显充血性心力衰竭 (CHF) 的终身风险.
- 评估高血压对心血管疾病终身风险的影响.
- 在没有心肌梗塞的情况下评估CHF的风险.
主要方法:
- 分析了来自弗雷明汉心脏研究中的3757名男性和4472名女性的数据,从1971年至1996年进行了跟踪.
- 在选定的指数年龄段计算终身CHF风险.
- 在不同血压水平的受试者之间,以及在没有心肌梗塞的情况下,对心脏梗塞风险的比较.
主要成果:
- 40岁时心血管衰竭的终身风险为男性21.0%,女性20.3%.
- 由于发病率的增加,终身风险在年龄的不同阶段保持一致.
- 血压≥160/100毫米升的受试者与血压<140/90毫米升的受试者相比,心血管衰竭的终身风险是140/90毫米升的两倍.
- 在没有先前心肌梗塞的情况下,40岁时心脏不全的终身风险为男性11.4%,女性15.4%.
结论:
- 确立的临床标准定义了男性和女性中5分之一的慢性心血管功能障碍的终身风险.
- 心血管梗塞的风险,特别是当心肌梗塞没有发生时 (男性为9分之一,女性为6分之一),受到高血压的显著影响.
- 这些发现强调了高血压控制和心肌梗塞预防在减轻CHF人口负担方面的重要性.
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