铜催化氧化物中的素交换:一种芳香的芬克尔斯坦反应
Artis Klapars1, Stephen L Buchwald
1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Journal of the American Chemical Society
|December 12, 2002
概括
一种新的铜催化反应有效地使用二胺联体将化物转化为化物,使用化物,化物和乙烯化物转化为化物. 这种温和的方法可以容忍各种功能组,为有机化学家提供了有价值的合成工具.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 合成方法论 合成方法论
背景情况:
- 素交换反应在有机合成中至关重要.
- 转化化,化和化为化的高效方法非常受欢迎.
- 现有的方法可能缺乏通用性或功能组容忍度.
研究的目的:
- 开发一种温和和通用的方法来合成酸,酸和酸.
- 探索铜化 (CuI) 和二联体在素交换反应中的实用性.
- 调查开发的合成方法的范围和局限性.
主要方法:
- 使用了一种利用铜 (I) 化物 (CuI) 和1,2-或1,3-胺联体的催化系统.
- 在各种溶剂中与化 (NaI) 反应化,化和乙烯基化.
- 通过改变催化剂负载,配体,化盐和溶剂来优化反应条件.
主要成果:
- 开发的方法实现了有效地将基化物,基化物和基化物转化为相应的化物.
- 反应表明了广泛的功能组耐受性,包括极性组和含有硫胺,胺和内醇等N-H基质的基质.
- 使用5mol%的CuI,10mol%的胺联体,10mol%的NaI作为化物来源,以及使用二氧化,n-butanol或n-pentanol等溶剂,获得了最佳的结果.
结论:
- 建立了一种温和,通用和高效的铜催化方法,用于从化物合成有机化物.
- 反应的成功取决于对化盐和溶剂的仔细选择.
- 这种方法为合成化学家的工具包提供了一个有价值的补充,用于获取各种有机化物.
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