催化不对称的转移反应以化物与酸作为源的酸转移反应
1Institut für Organische Chemie der RWTH-Aachen, Professor-Pirlet Strasse 1, 52074 Aachen, Germany. carsten.bolm@oc.rwth-aachen.de
Journal of the American Chemical Society
|December 12, 2002
概括
通过灵活的催化不对称方法,合成性二甲醇,这是生物活性化合物的关键中间体. 一个单一的平面 - 性铁催化剂可提供高选择性的两种产品反体.
科学领域:
- 有机化学 有机化学
- 不对称的合成方法
- 催化剂是一种催化剂.
背景情况:
- 化二甲基甲醇是合成生物活性分子的关键组成部分.
- 开发高效和灵活的方法来进行它们的不对称合成是非常有趣的.
研究的目的:
- 介绍一种多功能催化不对称的方法,用于合成奇拉性二甲基甲醇.
- 通过使用单一的催化剂系统来证明这两种产品酶体的可获得性.
主要方法:
- 使用平面-合体铁催化剂进行不对称的合成.
- 使用易于获得的酸和化物作为起始材料.
- 改变了基供体和接受体的组合,以控制基选择性.
主要成果:
- 实现了一种灵活且易于执行的奇拉性二甲基甲醇的合成.
- 证明了使用单一催化剂获取产品的两种酶体的能力.
- 获得了广泛的产品,具有优异的抗选择性,高达98% ee.
结论:
- 开发的方法提供了一个高效的途径,以奇拉的二甲基甲醇.
- 催化剂提供两种反体的能力简化了合成策略.
- 这种方法对于制备用于药物发现的纯净中间体具有价值.
相关概念视频
Chemiosmosis
Oxidative phosphorylation is a highly efficient process that generates large amounts of adenosine triphosphate (ATP), the basic unit of energy that drives many cellular processes. Oxidative phosphorylation involves two processes— the electron transport chain and chemiosmosis.
Electron Transport Chain
The electron transport chain involves a series of protein complexes on the inner mitochondrial membrane that undergo a series of redox reactions. At the end of this chain, the electrons reduce...
Electron Transport Chain
The electron transport chain involves a series of protein complexes on the inner mitochondrial membrane that undergo a series of redox reactions. At the end of this chain, the electrons reduce...
Acids, Bases and Neutralization Reactions
An acid-base reaction is one in which a hydrogen ion, H+, is transferred from one chemical species to another. Such reactions are of central importance to numerous natural and technological processes, ranging from the chemical transformations within cells or lakes and oceans to the industrial-scale production of fertilizers, pharmaceuticals, and other substances essential to the society.
Acid Halides to Carboxylic Acids: Hydrolysis
Hydrolysis of acid halides is a nucleophilic acyl substitution reaction in which acid halides react with water to give carboxylic acids. The reaction occurs readily and does not require acid or a base catalyst.
As shown below, the mechanism involves a nucleophilic attack by water at the carbonyl carbon to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen π bond along with the departure of a halide ion. A final proton transfer step yields carboxylic acid...
As shown below, the mechanism involves a nucleophilic attack by water at the carbonyl carbon to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen π bond along with the departure of a halide ion. A final proton transfer step yields carboxylic acid...
Acid-Catalyzed Aldol Addition Reaction
The aldol reaction of a ketone under acidic conditions successfully forms an unsaturated carbonyl as the final product instead of an aldol. The acid-catalyzed aldol reaction is depicted in Figure 1.
Types of Chemical Reactions: Exchange and Reversible
An exchange reaction is a chemical reaction in which both synthesis and decomposition occur, chemical bonds are both formed and broken, and chemical energy is absorbed, stored, and released.
A special kind of exchange reaction is the oxidation-reduction reaction, or the redox reaction. These reactions involve the transfer of electrons from one compound to another. The electrons in these reactions commonly come from hydrogen atoms, which consist of an electron and a proton. A molecule gives up a...
A special kind of exchange reaction is the oxidation-reduction reaction, or the redox reaction. These reactions involve the transfer of electrons from one compound to another. The electrons in these reactions commonly come from hydrogen atoms, which consist of an electron and a proton. A molecule gives up a...
Acids, Bases and Neutralization Reactions
Acids and bases play several important roles in biology. The pH of a biological system can significantly impact the function of biological molecules, including enzymes, proteins, and nucleic acids. For example, enzymes have optimal pH ranges for their activity, and changes in pH can denature or alter their structure, affecting their function. Acids and bases also play a crucial role in cellular signaling and communication. The pH of the extracellular fluid around cells can influence the...


