印梅他辛固体形式与氨气气体的反应性差异
Xiaoming Chen1, Kenneth R Morris, Ulrich J Griesser
1Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 47907-2051, USA.
Journal of the American Chemical Society
|December 12, 2002
概括
固态形式的印米他辛与氨气具有不同的反应性. 无形和转移稳定的α形式反应,而稳定的玛形式由于分子排列差异而保持惰性.
科学领域:
- 固态化学 固态化学
- 制药科学 制药科学 制药科学
- 材料科学是一种材料科学.
背景情况:
- 非类固醇抗炎药物 (NSAIDs) 如印米他辛存在各种固态形式.
- 了解这些形式的反应性对于药物配方和稳定性至关重要.
研究的目的:
- 为了研究不同固态形式的印梅他辛与氨气的酸反应.
- 阐明晶体结构,分子排列和反应性之间的关系.
主要方法:
- 射线粉的X射线衍射方法
- 光学显微镜是一种光学显微镜.
- 重力测量学是一种重力测量学.
- 频谱学方法 频谱学方法
主要成果:
- 无形印梅他辛易与氨气反应,形成无形盐.
- 转移稳定的α型反应产生微晶氨盐,在a轴上具有异性传播.
- 由于其晶体结构,稳定的玛形式对氨气是惰性的.
结论:
- 印梅他辛固体形式与氨气的反应性取决于分子排列,而不是包装密度.
- 阿尔法形式的暴露的碳酸组促进了反应,而在玛形式中它们是屏蔽的.
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