在胚胎分裂过程中,中心体局部化mRNA的不对称继承
1Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA.
Nature
|December 13, 2002
概括
科学家们发现了细胞在发育过程中传递信息的新方法. 传递 RNA (mRNA) 附着于中心体,然后不对称地分布到子细胞中,影响细胞命运.
科学领域:
- 发育生物学 发展生物学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 细胞命运的决定依赖于分子的不对称继承.
- 现有的机制涉及actin微纤维或皮质区域.
- 研究了一种不对称遗传的新机制.
研究的目的:
- 确定和描述软体动物胚胎中不对称遗传的新机制.
- 了解信使RNA (mRNA) 和中枢细胞在这个过程中的作用.
主要方法:
- 在细胞分裂过程中观察软体动物胚胎中的mRNA局部化.
- 调查微管和活性丝在mRNA运输中的作用.
- 实验性操纵中心体以评估mRNA向.
主要成果:
- 传递 RNA (mRNA) 与中心体结合,并在细胞分裂过程中局部不对称.
- 微管子依赖于mRNAs的定位到周围中心矩阵.
- 通过动氨酸丝介导的mRNAs运输到动物细胞皮层.
- 中核体差异决定了mRNA向,这是皮质局部化的先决条件.
结论:
- 已经确定了第三种不对称遗传机制,涉及与中心体相关的mRNAs.
- 这种机制有助于细胞命运的复杂的空间和时间模式.
- 不同的mRNA局部化为具有相似发展潜力的细胞提供了不同的分子身份.
相关概念视频
Cleavage and Blastulation
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
Inheritance of Chromatin Structures
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Centrosome Duplication
The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
Determining the Plane of Cell Division
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Centrosome Duplication
The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
Centrioles and Centrosomes
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or "prometaphase,"...
Near the end of the prophase, also called late prophase or "prometaphase,"...


