关于蜂信号联盟的概述
Alfred G Gilman1, Melvin I Simon, Henry R Bourne
1Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Nature
|December 13, 2002
概括
蜂信号联盟绘制了蜂通信网络的地图. 这项研究侧重于免疫B淋巴细胞和心脏肌细胞,以推进定量建模和公开共享数据,以促进全球科学发现.
科学领域:
- 细胞生物学 细胞生物学
- 系统生物学 系统生物学
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
背景情况:
- 细胞信号网络是生物过程的基础.
- 了解这些网络对于应对全球卫生挑战至关重要.
- 以前的研究往往是分散的,限制了全面的分析.
研究的目的:
- 建立一个大规模的合作,调查细胞信号通路.
- 为了促进信号网络的定量建模.
- 通过使数据自由可访问,催化补充性研究.
主要方法:
- 密集研究两个关键细胞类型的信号通路:B淋巴细胞和心脏肌细胞.
- 应用定量建模方法.
- 建立一个数据共享基础设施.
主要成果:
- 为蜂信号数据开发一个全面的资源.
- 在B淋巴细胞和心脏肌细胞中识别关键信号通路.
- 通过开放数据访问促进跨学科研究.
结论:
- 蜂信号联盟为理解复杂的信号网络提供了一个强大的框架.
- 开放的数据访问加速了科学发现和协作研究.
- 这一举措有可能显著推进细胞生物学,免疫学和心脏病学.
相关概念视频
Cell-surface Signaling
Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
What is Cell Signaling?
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
What is Cell Signaling?
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Diversity in Cell Signaling Responses
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...


