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相关概念视频

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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相关实验视频

Updated: Jul 16, 2026

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals
06:46

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Published on: January 5, 2016

蛋白酶抑制剂和艾滋病毒-1患者的心血管结果.

Scott D Holmberg1, Anne C Moorman, John M Williamson

  • 1Division of HIV/AIDS Prevention, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA. sdh1@cdc.gov

Lancet (London, England)
|December 14, 2002
PubMed
概括

用于HIV-1治疗的蛋白酶抑制剂可能会增加心脏病发作的风险. 这项研究发现,使用这些药物的患者心肌梗塞的频率更高.

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科学领域:

  • 心脏病学 心脏病学
  • 传染性疾病 传染性疾病
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 蛋白酶抑制剂 (PI) 对于治疗人类免疫缺陷病毒1型 (HIV-1) 是至关重要的.
  • 之前的研究表明PI和代谢障碍 (如高脂血症和高血糖症) 之间存在联系.
  • 与PI治疗相关的潜在心血管风险需要进一步调查.

研究的目的:

  • 研究HIV-1感染患者使用蛋白酶抑制剂与心肌梗塞 (MI) 风险之间的关联.
  • 量化接受PI治疗的HIV-1患者心脏病发作风险.

主要方法:

  • 一项对来自美国9家诊所的5672名HIV-1门诊患者的队列研究 (1993-2002).
  • 在服用PI和不服用PI的患者之间比较MI发病率.
  • 使用概率比率和考克斯比例危险模型进行统计分析,以相关共变量进行调整.

主要成果:

  • 在1996年PI引入后,心肌梗塞的频率增加了 (p=0.0125).
  • 服用PI的患者患心肌梗塞的风险显著增加 (几率比7.1,95% CI 1.6-44.3).
  • 经过调整后的分析表明,使用PI增加了心脏病发作风险的趋势 (危险比率6.5,0.9-47.8).

结论:

  • 在HIV-1治疗中使用蛋白酶抑制剂与心肌梗塞风险增加有关.
  • 虽然很少发生,但这种心血管风险在治疗PI的HIV-1患者的管理中需要考虑.
  • 可能需要进一步的研究来阐明机制并证实这些发现.