长期体内成像成年人皮质的经验依赖的突触可塑性
Joshua T Trachtenberg1, Brian E Chen, Graham W Knott
1Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Nature
|December 20, 2002
概括
在成年大脑皮层中形成新的突触,有些持续数周,有些持续数天. 这种由感官体验驱动的突触周转,是神经回路重塑和可塑性的基础.
科学领域:
- 神经科学是一个神经科学.
- 突触性可塑性 突触性可塑性
- 皮层发育 皮层发育
背景情况:
- 成年大脑的结构和功能适应能力,称为可塑性,对于学习和记忆至关重要.
- 突触 (神经元之间的连接) 的形成和消除是这种可塑性背后的关键机制.
研究的目的:
- 调查成人皮层是否形成新的突触以支持经验依赖的可塑性.
- 量化成年老鼠皮层中突触形成和消除的动态.
主要方法:
- 在几周的时间里,在老鼠大脑皮层中,对单个金字塔神经元进行了反复的体内成像.
- 序列截面电子显微镜以追溯分析脊柱动态和突触形成/消除.
- 突触周转与皮质受体场的经验依赖性可塑性之间的相关性.
主要成果:
- 虽然树突结构在很大程度上保持稳定,但单个树突脊柱表现出动态行为,具有显著的脊柱形成和消除.
- 脊柱的寿命差异很大,大约50%的脊柱持续超过一个月,其余的持续几天或更短时间.
- 观察到突触周转率增加,以脊柱发芽和收缩为特征,并且与皮层受体场中的经验依赖可塑性相关.
结论:
- 突触形成和消除在成人皮层中发生动态,挑战了静态成熟神经回路的概念.
- 感官体验积极推动突触的周转,这表明适应性神经电路重塑的机制.
- 这些动态突触变化可能是成年哺乳动物大脑体验依赖可塑性的基础.
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