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Updated: Jul 15, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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在新合成的多域蛋白中协调的非向量折叠

Annemieke Jansens1, Esther van Duijn, Ineke Braakman

  • 1Department of Bio-Organic Chemistry 1, Bijvoet Center for Biomolecular Research, University of Utrecht, Padualaan 8, 3584 CH Utrecht, Netherlands.

Science (New York, N.Y.)
|December 21, 2002
PubMed
概括

新合成的低密度脂蛋白受体 (LDL-R) 分子通过崩的中间体在翻译后折叠. 这个过程涉及短暂的,长距离的二硫化物键,后者被异构化成原生对,挑战了矢量折叠假设.

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