一个关于昼夜节律起器的网络
Ueli Schibler1, Paolo Sassone-Corsi
1Department of Molecular Biology, NCCR Frontiers in Genetics, Sciences II, University of Geneva, Switzerland. ueli.schibler@molbio.unige.ch
Cell
|January 1, 2003
概括
哺乳动物的身体有许多内部时钟,需要由中央起器同步以实现协调功能. 最近的研究正在推动我们对这些中央和外围时钟如何通信的理解.
科学领域:
- 时间生物学 时间生物学
- 生理学 生理学 生理学
- 神经科学是一个神经科学.
背景情况:
- 哺乳动物的昼夜计时系统涉及到个体细胞钟的庞大网络.
- 这些多个振荡器由中央节拍器同步,对于协调生理和行为至关重要.
- 了解中央起器和外围时钟之间的通信是一个活跃的研究领域.
研究的目的:
- 探索哺乳动物中中央起器和外周时钟之间的关系.
- 调查基础的沟通机制与昼夜节律的同步.
主要方法:
- 这项研究可能涉及分析现有的文献和关于昼夜节律的实验数据.
- 方法可能包括计算建模或实验验证时钟同步.
主要成果:
- 在阐明大脑的中央时钟与身体其他部位的时钟之间的联系方面取得了进展.
- 正在确定促进时间协调的关键通信通道.
结论:
- 中心节拍器对外围时钟的同步对于哺乳动物的时间组织至关重要.
- 对这些通信机制的进一步研究将提高我们对昼夜调节的理解.
相关概念视频
Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
RLC Circuit as a Damped Oscillator
An RLC circuit combines a resistor, inductor, and capacitor, connected in a series or parallel combination.
Consider a series RLC circuit. Here, the presence of resistance in the circuit leads to energy loss due to joule heating in the resistance. Therefore, the total electromagnetic energy in the circuit is no longer constant and decreases with time. Since the magnitude of charge, current, and potential difference continuously decreases, their oscillations are said to be damped. This is...
Consider a series RLC circuit. Here, the presence of resistance in the circuit leads to energy loss due to joule heating in the resistance. Therefore, the total electromagnetic energy in the circuit is no longer constant and decreases with time. Since the magnitude of charge, current, and potential difference continuously decreases, their oscillations are said to be damped. This is...
Characteristics of OpAmp
The operational amplifier, commonly known as an op-amp, is a specially designed electronic circuit component. Its purpose is to work in conjunction with other circuit elements to execute a defined signal-processing operation. Consider an equivalent circuit model of an op-amp, as depicted in Figure 1; the output section comprises a voltage-controlled source in parallel with the output resistance Ro.
Instrumentation Amplifier
An electrocardiography (ECG) machine is an essential piece of medical equipment used to monitor the electrical activity of the heart. It operates by detecting small electrical changes on the skin that result from the depolarization of the heart muscle during each heartbeat. However, these signals are in the microvolt range and can be easily overwhelmed by noise or interference.
To overcome this challenge, an ECG machine utilizes an instrumentation amplifier. This specialized amplifier is...
To overcome this challenge, an ECG machine utilizes an instrumentation amplifier. This specialized amplifier is...
Network Function of a Circuit
Frequency response analysis in electrical circuits provides vital insights into a circuit's behavior as the frequency of the input signal changes. The transfer function, a mathematical tool, is instrumental in understanding this behavior. It defines the relationship between phasor output and input and comes in four types: voltage gain, current gain, transfer impedance, and transfer admittance. The critical components of the transfer function are the poles and zeros.


