静脉注射levosimendan持续的血液动力学影响
Matti Kivikko1, Lasse Lehtonen, Wilson S Colucci
1Orion Pharma, Clinical Research, Espoo, Finland.
Circulation
|January 8, 2003
概括
莱沃西门丹 (Levo) 输液在心力衰竭患者中维持了48小时的血液动力学改善. 它的活性代谢物OR-1896在药物停用后也能延长这些效果.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
背景情况:
- 短期levosimendan (Levo) 输液改善了无补偿性心力衰竭中的血液动力学.
- 莱沃西门丹的代谢物具有很长的半衰期,并且具有血液动力学活性.
- 这项研究调查了输注期间和输注后Levo的持续血液动力学影响.
研究的目的:
- 为了评估长期输液期间levosimendan持续的血液动力学效应.
- 为了确定血动力学效应是否在停止服用levosimendan后仍然存在.
- 评估活性代谢物在长时间药物作用中的作用.
主要方法:
- 患有无补偿性心力衰竭的患者接受了升级性静脉注射levosimendan或安慰剂6小时.
- 接受levosimendan治疗的患者继续开放标签药物24小时,然后随机分配到24小时的levosimendan或安慰剂.
- 血动力学参数,levosimendan和活性代谢物OR-1896的血度都被监测.
主要成果:
- 血动力学效应在48小时后在Levosimendan继续和戒断组中保持.
- 利沃西曼丹的血度在戒药后迅速下降,但活性代谢物OR-1896的水平保持相似,并显著增加.
- 在两组中,活性代谢物OR-1896在48小时内增加了3.5倍至4倍.
结论:
- 莱沃西门丹的血液动力学效应在48小时的输液中持续,并在输液后的24小时内持续.
- 活性代谢物OR-1896在levosimendan停止后增加,这可能解释了长时间的血液动力学益处.
- 这表明levosimendan在心力衰竭管理中的持续治疗作用.
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