磁共振图像引导的透导管关闭心房隔膜缺陷的心房缺陷
Carsten Rickers1, Michael Jerosch-Herold, Xudong Hu
1University of Minnesota, Department of Radiology, Minneapolis, Minn, USA.
Circulation
|January 8, 2003
概括
这项研究表明,磁共振成像 (MRI) 可以指导心房隔膜缺陷 (ASD) 的跨导管闭合. 实时MRI精确测量ASD大小和心脏变化,使设备的成功部署成为可能.
科学领域:
- 心血管成像 - 心血管成像
- 干预心脏病学 干预心脏病学
- 医疗器械技术 医疗器械技术
背景情况:
- 心脏MRI技术的进步使新的诊断和干预用途成为可能.
- 前庭隔膜缺陷 (ASD) 是一种常见的先天性心脏病,需要进行干预.
研究的目的:
- 为了评估MRI对二次体类型ASD的跨导管闭合的能力.
- 为了评估ASD大小和右心室体积在同一MRI检查期间的变化.
主要方法:
- 在猪模型中通过皮肤创建ASD.
- 高分辨率的MRI用于ASD成像和大小测定,与死后检查相关联.
- 实时MR光镜使用新型MR导线进行跨导管装置部署.
- 电影MRI用于计算干预前后的右心房和心室体积.
主要成果:
- 磁力共振成像准确地确定了ASD直径,与死后发现有很好的相关性 (r=0.97).
- 在实时MRI指导下成功跟踪和部署安普拉特泽隔膜封闭器.
- 在ASD关闭后右心房和心室体积显著减少 (P<0.005).
结论:
- 实时MRI指导是可行的使用血管内天线导线跨导管ASD关闭.
- 高分辨率的MRI能够准确地确定ASD的大小,并立即评估治疗对心脏体积的影响.
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