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Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
人类乳头瘤病毒18型和快速进展的宫内皮质瘤
Ciaran B J Woodman1, Stuart Collins, Terry P Rollason
1Centre for Cancer Epidemiology, University of Manchester, Withington, M20 4QL, Manchester, UK. ciaran.woodman@cce.man.ac.uk
Lancet (London, England)
|January 9, 2003
概括
人类乳头瘤病毒18型 (HPV-18) 感染与子宫癌有关,但其在高度子宫内皮质瘤 (CIN) 中的不足可能是由于低估了疾病严重程度,可能会影响查的有效性.
科学领域:
- 妇科瘤学 妇科瘤学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 人类乳头瘤病毒18型 (HPV-18) 是导致宫癌的重要原因之一,特别是腺癌.
- 与HPV-16相比,HPV-18在高度的宫内皮瘤 (CIN) 中矛盾地未被检测出来.
- 需要进行纵向研究,以了解HPV-18在宫瘤进展中的作用.
研究的目的:
- 为了调查发生HPV-18和HPV-16感染后细胞学异常的发生.
- 为了确定与HPV-18相关的宫病在入侵前阶段的进展是否与HPV-16不同.
主要方法:
- 一项对1075名年轻女性 (15-19岁) 的纵向研究,基线细胞学正常,HPV状态正常.
- 定期的6个月后续检查包括细胞学和病毒学样本采集.
- 分析的重点是HPV-18和HPV-16感染后细胞学异常的相对风险和时间.
主要成果:
- 感染HPV-18显示2.06增加边缘核异常的风险和3.11增加轻度硬化症的风险.
- 感染HPV-16的边界异常的风险增加了1.99,轻度硬化症的风险增加了4.76.
- 在HPV-18和HPV-16感染中,细胞学异常的时间相似,HPV-18与HPV-16 (2.85) 相比,中度/重度硬化症 (0.80) 的风险较低.
结论:
- 这些发现挑战了HPV-18相关疾病迅速进展的假设,解释了其在高等级CIN中的不足.
- 在HPV-18感染后的细胞学变化可能低估了潜在的宫疾病的实际严重程度.
- 这种低估可能会降低宫癌查计划在检测HPV-18相关癌症方面的有效性.
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