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相关概念视频

Blood Flow01:29

Blood Flow

Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Fertilization01:38

Fertilization

During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...

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相关实验视频

Updated: Jul 13, 2026

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

心内流体力量是胚胎心脏发生的重要表观遗传因素.

Jay R Hove1, Reinhard W Köster, Arian S Forouhar

  • 1Options of Bioengineering and Aeronautics, Division of Engineering & Applied Science, California Institute of Technology, Pasadena, California 91125, USA. jhove@caltech.edu

Nature
|January 10, 2003
PubMed
概括

血液流动模式对于心脏发育至关重要. 斑马鱼胚胎中的高切削力导致心脏异常形成,突出显示出血液动力学.

科学领域:

  • 发展生物学 发展生物学
  • 心血管生理学心血管生理学
  • 生物物理学的生物物理.

背景情况:

  • 假设血液流动模式会影响心脏形态发生.
  • 室内内皮细胞通过改变细胞骨结构和基因表达来响应流动力.

研究的目的:

  • 在体内定量分析斑马鱼胚胎发育中的心内流动力.
  • 将体外发现的流动诱导的细胞反应与完整的发育中的心脏联系起来.
  • 为了研究心内血动力学在胚胎心脏生成中的作用.

主要方法:

  • 在斑马鱼胚胎中的心内血液流量的定量体内成像.
  • 基于观察到的流动模式来预测流动诱导的力.
  • 心脏输入或输出通道的体内封闭,以破坏正常的血液流动.

主要成果:

  • 在斑马鱼心脏发育的关键阶段确定了高剪切,旋流.
  • 预测的心内流动力明显高于微型系统的预期.
  • 流塞导致心脏缺陷,包括异常的第三腔,受损的循环和缺陷的门形成.

结论:

  • 心内血动力学,以高剪切力为特征,对正常的胚胎心脏发育至关重要.

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Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
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A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System
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A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System

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En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
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En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

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  • 在体内正常血流模式的破坏会导致与生俱来的类似心脏的缺陷.
  • 血动力学力量作为影响心脏发生的关键表观遗传因素.