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Updated: Jul 15, 2026

Rapid Synthesis and Screening of Chemically Activated Transcription Factors with GFP-based Reporters
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Published on: November 26, 2013

对于指转录因子的小分子开关

Qing Lin1, Carlos F Barbas, Peter G Schultz

  • 1Department of Chemistry and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, The Scripps Research Institute, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|January 16, 2003
PubMed
概括

研究人员创造了一种新的方法来设计用于指转录因子的小分子开关. 发现一种特定的化合物 (7) 可以恢复受损的转录因子的功能,证明了针对性基因调节的潜力.

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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