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Updated: Jul 5, 2026

Using RNA-mediated Interference Feeding Strategy to Screen for Genes Involved in Body Size Regulation in the Nematode C. elegans
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对Caenorhabditis elegans脂肪调节基因的全基因组RNAi分析

Kaveh Ashrafi1, Francesca Y Chang, Jennifer L Watts

  • 1Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Nature
|January 17, 2003
PubMed
概括

研究人员对C. elegans基因组进行了选,以确定调节身体脂肪储存的基因. 这项研究揭示了新的脂肪调节基因,其中一些在物种中保存,为肥胖治疗提供了潜在的目标.

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Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...