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血液稀释在患有晚期心力衰竭的患者中很常见
Ana-Silvia Androne1, Stuart D Katz, Lars Lund
1Department of Medicine, Columbia University, New York, NY, USA.
Circulation
|January 23, 2003
概括
贫血在慢性心力衰竭 (CHF) 患者中很常见,并且与更糟糕的结果有关. 血液稀释,血体积的增加,在CHF中很常见,并且与比真正贫血更糟糕的生存率有关.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 内部医学 内部医学
背景情况:
- 慢性心力衰竭 (CHF) 患者中贫血很普遍,与预后不佳相关.
- 低血红素在CHF可以源于血体积增加 (血液稀释) 或减少红细胞体积 (真正的贫血).
- 血液稀释在CHF患者中的患病率和临床影响在很大程度上是未知的.
研究的目的:
- 在慢性心力衰竭患者中调查贫血和血液稀释的患病率.
- 检查贫血,血液稀释和心血管衰竭的临床结果之间的关联.
- 探索潜在的机制背后的贫血的CHF患者的不良预后.
主要方法:
- 研究了一组196名患有慢性心力衰竭 (CHF) 的患者.
- 评估了贫血患病率及其与纽约心脏协会 (NYHA) 功能类的相关性.
- 红细胞和血体积测量在37名贫血的CHF患者使用I131标记的白蛋白来区分血液稀释和真正的贫血.
主要成果:
- 在61%的CHF患者中存在贫血,从NYHAII类的33%增加到IV类的68%.
- 与非贫血患者相比,贫血的CHF患者的生存率降低 (P<0.05).
- 在贫血患者中,46%有血液稀释,54%有真正的贫血. 血液稀释与更高的死亡率或紧急移植相关 (P<0.04).
结论:
- 血液稀释是慢性心力衰竭 (CHF) 患者的常见发现.
- 贫血是心血管衰竭预后不佳的重要预测因素.
- 血液稀释患者的结果比真正贫血患者更糟糕,这表明体积过载是导致的因素.
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