心脏结果预防评估 (HOPE) 研究中的多种感染和随后的心血管事件
Marek Smieja1, Judy Gnarpe, Eva Lonn
1Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Circulation
|January 23, 2003
概括
细胞巨乳病毒 (CMV) 暴露,但不是其他感染,在HOPE研究患者中略有增加心血管疾病风险. 综合病原体评分也预测了心脏病发作,中风或心血管死亡的风险更高.
科学领域:
- 传染病流行病学 传染病流行病学
- 心血管疾病的研究研究.
背景情况:
- 有限的前性数据存在于诸如冠状病毒肺炎,Helicobacter pylori,细胞巨型病毒 (CMV),甲型肝炎病毒 (HAV) 和心血管疾病 (CV) 等感染.
- 研究这些病原体对心血管结果的单独和综合影响至关重要.
研究的目的:
- 评估暴露于C. pneumoniae,H. pylori,CMV和HAV,单独和作为总病原体得分,与心血管疾病之间的关联.
- 确定这些感染是否预测未来的心血管事件,如心肌梗塞,中风或心血管死亡.
主要方法:
- 从3168名加拿大患者的注册血清分析心脏结果预防评估 (HOPE) 研究.
- 对C.肺炎,H.pylori,CMV和HAV的抗体的测量.
- 血清状况与4.5年内494个被判定心血管结果的相关性.
主要成果:
- 细胞巨乳病毒 (CMV) 血清状况与心血管事件的风险增加有关 (调整HR,1.24).
- 冠状病毒肺炎,H. pylori和HAV血清状况没有预测心血管事件.
- 结合这些感染的病原体总得分与心血管事件的增加有关 (针对4种病原体的调整HR与0或1=1.41).
结论:
- 与C. pneumoniae,H. pylori或HAV不同的是,CMV暴露显示出随后心肌梗塞,中风或心血管死亡的风险略高.
- 总病原体评分表明,在研究人群中,心血管事件的风险略微增加.
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