心力衰竭患者的骨肌反射:的作用
Adam C Scott1, Roland Wensel, Constantinos H Davos
1National Heart and Lung Institute, and Royal Brompton Hospital, Imperial College School of Science, Technology and Medicine, London, United Kingdom.
Circulation
|January 23, 2003
概括
增加的肌肉酸度 (H+) 过度激活慢性心力衰竭 (CHF) 中的运动受体,导致不耐受性. 碳酸输液减少了H+和正常化了人体体受体活动,这表明H+起着关键作用.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 骨肌肉生理学 骨肌肉生理学
背景情况:
- 骨肌肉的机能受体与慢性心力衰竭 (CHF) 中的运动不耐受性有关.
- 这些受体的过度激活可能源于肌肉工作的代谢副产品增加的刺激.
研究的目的:
- 调查H +,K +,乳酸和外周血动力学在CHF的ergoreflex过度激活中的作用.
- 为了确定调节这些因素是否可以使人体反射活动正常化.
主要方法:
- 研究了10名心血管衰竭患者和10名健康对照.
- 评估了使用手握后区域循环阻塞 (PH-RCO) 对通风的厄戈反射贡献.
- 选择性输注 (胰岛素,酸,二碳酸,多巴胺,盐水) 和无葡萄糖饮食,测量肌肉废水中的H+,K+,葡萄糖和乳酸盐度.
主要成果:
- 慢性心血管疾病患者在盐水输注期间对通风产生了人体反射效应 (6.7+/-2.3 L/min,对照组 -0.1+/-0.5 L/min,P<0.01).
- 二碳酸盐输注显著降低了人体反射活动 (0.4+/-0.3 L/min对照组 -0.2+/-0.4 L/min,P=NS;对照组盐水 P<0.05).
- 碳酸还降低了运动期间肌肉的H+度 (47.4+/-1.3与盐水中的50.0+/-1.4nmol/L相比,P<0.05).
结论:
- 通过二碳酸盐输液降低的H+度消除了CHF中人体受体活性增加.
- 这些发现表明H+在慢性心力衰竭中直接或间接地在人体反射激活中起着重要作用.
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