自然,培养和人类疾病
Aravinda Chakravarti1, Peter Little
1McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Jefferson Street Building, 2-109, Baltimore, Maryland 21287, USA. aravinda@jhmi.edu
Nature
|January 24, 2003
概括
在DNA发生50年后.
科学领域:
- 遗传学和分子生物学
- 人类生物学 人类生物学
- 疾病病因学 疾病病因学
背景情况:
- 发现DNA的结构彻底改变了生物学.
- 了解人类生物学和常见疾病仍然是一个重大挑战.
- 遗传与环境之间的相互作用尚未完全阐明.
研究的目的:
- 评估DNA结构发现对理解人类生物学和疾病的影响.
- 识别有关常见疾病原因的当前知识的局限性.
- 提出将环境因素纳入DNA范式的框架.
主要方法:
- 关于DNA,人类生物学和常见疾病的科学文献的审查.
- 分析仅通过遗传学解释疾病病因学的局限性.
- 开发概念框架,将环境影响纳入DNA层面.
主要成果:
- 尽管发现了DNA,但对人类个体生物学和常见疾病的全面理解仍然缺乏.
- "培养"方面 (环境影响) 仍然是DNA范式中的一个重要差距.
- 假设环境因素会影响DNA层面的生物过程.
结论:
- 环境影响必须在DNA层面上理解,才能充分理解常见的疾病原因.
- 未来的研究应该专注于表观遗传学和环境与DNA的相互作用.
- 需要一个范式的转变,以纳入环境因素,以完全了解人类的健康和疾病.
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