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Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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相关实验视频

Updated: Jun 25, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
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埃普斯坦-巴尔病毒 (EBV) 阳性移植后淋巴增殖性疾病的细胞:与EBV阳性霍奇金淋巴瘤有相似之处.

Judith M Timms1, Andrew Bell, Joanne R Flavell

  • 1Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK.

Lancet (London, England)
|January 28, 2003
PubMed
概括
此摘要是机器生成的。

移植后淋巴增殖性疾病 (PTLD) 可以源自各种B细胞类型,而不仅仅是记忆细胞. 爱斯坦-巴尔病毒 (EBV) 可能会拯救和扩展B细胞,这些B细胞无法正常选择,将PTLD与霍奇金病联系起来.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.
  • 病毒学 病毒学

背景情况:

  • 艾普斯坦-巴尔病毒 (EBV) 相关的移植后淋巴增殖性疾病 (PTLD) 呈现出各种各样的病变.
  • 这些病变是由免疫功能低下个体中EBV感染的B细胞的扩大群体引起的.
  • 澄清PTLD的细胞起源对于理解其病变发生至关重要.

研究的目的:

  • 为了确定EBV阳性PTLD病变的精确细胞起源.
  • 调查PTLD病原和EBV感染动态之间的关系.

主要方法:

  • 对13例EBV阳性PTLD病例的组织学分析.
  • 评估EBV基因表达模式.
  • 在11个单克隆/双克隆病变中使用免疫球蛋白重链 (IgH) 基因定型来确定原始B细胞的起源.

主要成果:

  • 两个PTLD瘤起源于纯粹的B细胞.
  • 两种瘤来自抗原选择的B细胞.
  • 七种瘤起源于具有异常IgH基因型的生殖后中心B细胞,这表明EBV的救援.

结论:

  • PTLD可以源于比以前想象的更广泛的B细胞谱,包括天真和非典型的后生殖中心细胞.
  • 似乎EBV拯救和扩展了未能选择生理生殖中心的B细胞.
  • 这一发现揭示了PTLD病原和EBV阳性霍奇金淋巴瘤之间的联系,这两种淋巴瘤都涉及非典型的后生殖中心B细胞.