ARF激活剂GNOM的内分体特定定位和功能
Juan S Bonifacino1, Catherine L Jackson
1Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
阿拉比多普西斯的ARF激活剂GNOM通过局部化到内分泌体,控制了辅酶流动载体PIN1向基底血的两极流通. 这项研究揭示了植物细胞贩运中ARF激活的空间调节.
科学领域:
- 植物细胞生物学 植物细胞生物学
- 分子植物科学 分子植物科学
- 蜂通讯贩运活动
背景情况:
- ADP-ribosylation factor (ARF) GTPases是细胞内贩运通路的关键调节者,包括分泌和真空/溶酶通路.
- 控制ARF激活的精确空间控制机制在很大程度上是未知的,这阻碍了对它们多样化的细胞作用的全面理解.
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