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Updated: Jan 7, 2026

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
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通过分子间自酸化和二聚体解离,DNA损伤激活了ATM

Christopher J Bakkenist1, Michael B Kastan

  • 1Department of Hematology-Oncology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA.

Nature
|January 31, 2003
PubMed
概括

对于DNA损伤反应至关重要的ATM蛋白激酶被电离辐射激活. 辐射导致ATM自酸化,导致二元解离,并启动细胞修复的激酶活性.

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