关于乳腺癌预防试验的主要结果的概述
J Cuzick1, T Powles, U Veronesi
1Cancer Research UK, London, UK. jack.cuzick@cancer.org.uk
Lancet (London, England)
|February 1, 2003
概括
塔莫西芬显著降低了雌激素受体阳性乳腺癌的发生率,但增加了子宫内膜癌和静脉血栓栓事件. 需要进一步的研究来预防ER阴性乳腺癌,并减轻他莫西芬的副作用.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 预防医学 预防医学
背景情况:
- 在乳腺癌预防中使用塔莫西芬和拉洛西芬的混合早期发现.
- 需要更新数据和预防试验的综合结果.
研究的目的:
- 更新有关乳腺癌预防的塔莫西芬和拉洛西芬的现有数据.
- 概述随机预防试验的综合结果.
主要方法:
- 包括所有五项随机预防试验,将他莫西芬或拉洛西芬与安慰剂进行比较.
- 包括从辅助性他莫西芬试验中获得的关于逆侧乳腺瘤和副作用的数据.
主要成果:
- 塔莫西芬减少了38%的乳腺癌发病率,主要是ER阳性病例 (48%的减少).
- 塔莫西芬增加了子宫内膜癌的风险 (RR 2.4) 和静脉血栓栓塞事件 (RR 1.9).
- 拉洛西芬没有显示出子宫内膜癌的增加,但也增加了静脉血栓栓塞事件.
结论:
- 塔莫西芬有效降低了ER阳性乳腺癌的风险.
- 需要新的策略来预防ER阴性乳腺癌,并减少他莫西芬的副作用.
- 进一步评估新的药物,如拉洛西芬和芳酶抑制剂是必要的.
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