成年人的原发性脑瘤
Anthony Behin1, Khe Hoang-Xuan, Antoine F Carpentier
1Fédération de Neurologie Mazarin, G H Pitié-Salpêtrière, 75013, Paris, France.
Lancet (London, England)
|February 1, 2003
概括
成年人脑瘤,如质瘤和初级中枢神经系统淋巴瘤,需要先进的分类和治疗. 虽然分子遗传学有助于结质瘤治疗,但结质母细胞瘤仍然是缓解性,而初级中枢神经系统淋巴瘤疗法在老年患者中引发了神经毒性问题.
科学领域:
- 神经瘤学神经瘤学
- 大脑瘤的分子遗传学
- 在中枢神经系统恶性瘤中进行化疗和放射治疗.
背景情况:
- 质瘤和初级中枢神经系统淋巴瘤是成年人中最常见的大脑瘤.
- 分子遗传分析对于质瘤的分类和治疗计划越来越重要.
- 质母细胞瘤的治疗仍然主要是缓解性治疗.
研究的目的:
- 审查当前成人初级脑瘤的情况,重点关注质瘤和初级中枢神经系统淋巴瘤.
- 突出分子遗传学在质瘤管理中的作用.
- 讨论初级中枢神经系统淋巴瘤的治疗进展和挑战,特别是关于神经毒性的问题.
主要方法:
- 关于成人初级脑瘤的当前文献的综述.
- 在质瘤分类中的分子遗传发现的分析.
- 评估初级中枢神经系统淋巴瘤的治疗策略,包括化疗和放射治疗.
主要成果:
- 分子遗传学已经改进了分类,并确定了化学敏感的小腺瘤.
- 质母细胞瘤治疗在很大程度上是缓解性治疗.
- 主要中枢神经系统淋巴瘤的发病率有所上升;基于甲基酸盐的化疗与放射治疗在免疫能力强的患者中取得进展,但对老年人来说具有神经毒性风险.
结论:
- 分子遗传学的进步正在改变质瘤治疗.
- 对质母细胞瘤的有效治疗仍然是一个未得到满足的需求.
- 虽然在初级中枢神经系统淋巴瘤治疗方面取得了进展,但对神经毒性的仔细考虑至关重要,特别是在老年人群中.
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