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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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在患有急性冠状动脉综合征的患者中,血管生长因子血清水平的预后意义

Christopher Heeschen1, Stefanie Dimmeler, Christian W Hamm

  • 1Department of Internal Medicine IV, Molecular Cardiology, University of Frankfurt, Germany. c.heeschen@em.uni-frankfurt.de

Circulation
|February 5, 2003
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概括

血管内皮生长因子 (VEGF) 和肝细胞生长因子 (HGF) 的血清水平预测了急性冠状动脉综合征的结果. 高VEGF表明更糟糕的预后,而高HGF与更好的抵押和更好的结果有关.

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科学领域:

  • 心脏病学 心脏病学
  • 生物医学研究生物医学研究
  • 分子生物学分子生物学

背景情况:

  • 急性冠状动脉综合征会触发诸如血管生成和斑块修复之类的补偿过程.
  • 血管新生因素,包括血管内皮生长因子 (VEGF),肝细胞生长因子 (HGF) 和基本纤维细胞生长因子 (bFGF),在缺血期间增加.
  • 这些生长因子的血清水平与急性冠状动脉综合征的临床结果之间的关系尚不清楚.

研究的目的:

  • 研究VEGF,HGF和bFGF血清水平与急性冠状动脉综合征患者的临床结果之间的关联.
  • 确定这些血管新生因素是否是该患者群体预后的独立预测因素.

主要方法:

  • 在1090名被诊断患有急性冠状动脉综合征的患者中测量了VEGF,HGF和bFGF的血清水平.
  • 血管造影评估是在基线进行的.
  • 在6个月的随访期间记录了临床结果,包括死亡和非致命的心肌梗塞.

主要成果:

  • 血清中的HGF和VEGF水平都与患者的结果有显著且独立的关联,而bFGF则没有.
  • 升高的VEGF水平与不良结果相关 (调整后的危险比,2.50;P=0.002) 并与缺血有关.
  • 高HGF水平与较低的事件率相关 (调整后危险比,0.33;P<0.001),独立于缺血症,并与改善的抵押相关.

结论:

  • 在急性冠状动脉综合征中,VEGF和HGF是独立的预后预测因素.
  • 增高VEGF意味着不良结果,与心肌缺血相关.
  • 独立于缺血的HGF升高与增强的担保和有利的预后有关.