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在老鼠的侧面预视损伤中,将饮水的冲动与饮用水的数量分开

M H Teicher, E M Blass

Science (New York, N.Y.)

|March 19, 1976

概括

带有侧面前视区域病变的老鼠在脱水时不会喝水,但在缺水时会喝水. 这表明喝酒的冲动与消耗的液体量是分开的.

科学领域:

神经科学是一个神经科学.
生理学生理学生理学
行为科学行为科学

背景情况:

侧面前视区域 (LPOA) 对于调节口渴和饮酒行为至关重要.
了解口渴的神经机制对于理解液体平衡至关重要.

研究的目的:

研究侧向前视区域在不同生理条件下调解饮酒行为的作用.
为了确定饮酒的冲动是否可以与摄入的液体量分离.

主要方法:

在老鼠中诱导细胞内脱水和缺水.
在实验大鼠的侧向前视区域创建双边病变.
测量饮酒行为和杆压力率作为口渴和动机的指标.

主要成果:

患有LPOA病变的老鼠在急性细胞内脱水后没有喝水.
受损的老鼠在缺水后表现出正常的饮酒行为.
虽然正常的老鼠在脱水和剥夺的情况下增加了饮酒和杆压力,但受伤的老鼠只增加了饮酒,而不是杆压力.

结论:

侧向前视区域在响应细胞脱水时启动饮酒行为方面发挥着至关重要的作用.
饮酒行为可以分为与饮酒冲动和消耗的液体量相关的组件.
这些发现凸显了干渴调节背后的复杂神经电路.

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