在高风险无症状人群中检测隐性冠状动脉疾病
Roger S Blumenthal1, Diane M Becker, Lisa R Yanek
1Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. rblument@jhmi.edu
Circulation
|February 13, 2003
概括
无症状个体的异常运动压力测试与冠状动脉疾病 (CAD) 的家族史往往表明轻度动脉样硬化,而不是严重的阻塞. perfusion 缺陷可能源于血管运动功能障碍或斑块.
科学领域:
- 心脏病学 心脏病学
- 诊断成像 诊断成像 诊断成像
- 预防医学 预防医学
背景情况:
- 运动压力测试和输液成像是诊断症状患者阻塞性冠状动脉疾病 (CAD) 的标准.
- 在无症状的个体中,有过早CAD家族病史的异常功能性运动测试的意义仍然不清楚.
研究的目的:
- 调查异常运动测试结果与冠状动脉样硬化的严重程度在无症状的个人与CAD的家族史之间的相关性.
主要方法:
- 评估了734名无症状的CAD患者的兄弟姐妹.
- 153人有异常的运动测试,扫描或两者兼而有之.
- 105名患者接受了冠状动脉动图,以进行定量狭窄症分析.
主要成果:
- 95%的参与者患有冠状动脉样硬化;只有39%的参与者患有狭窄症>=50%.
- 在那些有两种异常测试的人中,70%的人患有狭窄症>=50%.
- 输血缺陷的动脉输血缺陷的平均狭窄率为43+/-31%,其中68%<50%.
结论:
- 在无症状的个体中,有CAD家族病史的异常运动光学扫描主要识别轻度冠状动脉样硬化.
- perfusion 缺陷可能是冠状动脉血管功能障碍以及动脉样硬化斑块造成的.
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