鉴定可溶血清ST2受体作为一种新的心力衰竭生物标志物
Ellen O Weinberg1, Masahisa Shimpo, Shelley Hurwitz
1Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Circulation
|February 13, 2003
概括
在心力衰竭血清中溶解的ST2是一种用于神经激素激活的新生物标志物. 溶性ST2水平的变化独立地预测严重心力衰竭患者的死亡率或移植.
科学领域:
- 心脏病学 心脏病学
- 生物标志物发现发现
- 基因组学就是基因组学.
背景情况:
- 介质素-1受体家族成员ST2是由心脏肌细胞中的机械应变引起的.
- 可溶性ST2 (sST2) 在人体血清中分泌和检测到.
- 这项研究研究了sST2作为心力衰竭中神经激素激活的生物标志物.
研究的目的:
- 测试一种假设,即在患有严重慢性心力衰竭和神经激素激活的患者中,可溶性ST2水平增加.
- 评估血清sST2水平与已确定的神经激素标志物之间的关联.
- 为了确定sST2的变化是否预测心力衰竭患者的结果.
主要方法:
- 分析了血清样本和PRAISE-2心力衰竭试验 (NYHA III-IV类) 的临床数据.
- 在基线和2周使用ELISA测量溶性ST2 (sST2) 血清水平.
- 评估了与B型性尿素 (BNP),前庭性性尿素 (ProANP) 和北上腺素的相关性.
主要成果:
- 基线的sST2水平与基线的BNP,ProANP和北上腺素正相关.
- sST2水平的变化是死亡率或移植的显著单变预测指标.
- 在多变量分析中,sST2的变化仍然是死亡率/移植的独立预测指标,即使考虑到BNP和ProANP.
结论:
- 血清可溶性ST2是一种用于心力衰竭中神经激素激活的新型生物标志物.
- 在sST2水平的变化独立地预测严重慢性心力衰竭 (NYHA类III-IV) 的后续死亡率或移植.
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