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Updated: Jul 9, 2026

Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos
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Mesd编码了一个LRP5/6的陪伴者,这对于指定小鼠胚胎极性至关重要

Jen-Chih Hsieh1, Lance Lee, Liqun Zhang

  • 1Department of Biochemistry and Cell Biology, Center for Developmental Genetics, State University of New York, Stony Brook, Stony Brook, NY 11794, USA.

Cell
|February 13, 2003
PubMed
概括

mesd基因对于建立胚胎极性和中皮诱导至关重要,它通过作为WNT信号核心受体的陪伴者来起作用. 它的干扰会损害早期发育,突出其在细胞信号通路中的作用.

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相关概念视频

Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...