间歇性和持续性息化疗用于晚期结直肠癌的比较:一个多中心随机试验
T S Maughan1, R D James, D J Kerr
1Department of Oncology, Velindre Hospital, Cardiff, UK.
Lancet (London, England)
|February 14, 2003
概括
对于晚期结直肠癌,在12周后停止化疗并重新开始进展是安全的. 这种间歇性化疗方法的毒性效应比连续治疗少,整体存活率没有显著差异.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 胃肠道癌症 胃肠道癌症
背景情况:
- 晚期结直肠癌的化疗持续时间在英国的临床医生之间有所不同.
- 缺乏一致的政策需要进行比较有效性研究.
研究的目的:
- 为了比较持续与间歇性化疗在晚期结直肠癌中的有效性.
- 评估两种化疗策略之间的安全性和生存结果.
主要方法:
- 患有晚期结直肠癌的患者,在经过12周的特定化疗方案后反应或稳定,被随机分配.
- 间歇性组:化学疗法暂停,在进展后重新开始. 连续组:化学疗法直到进展.
主要成果:
- 共有354名患者参加了这项研究. 间歇性化疗导致毒性影响和严重不良事件显著减少.
- 间歇性和连续化疗组之间没有观察到总生存时间的明显差异.
- 只有37%的间歇性治疗患者按计划重新开始治疗.
结论:
- 无限期地继续化疗,直到疾病进展没有明显的生存益处.
- 在12周后停止化疗,并在进展后重新开始是对化学敏感性晚期结直肠癌的安全策略.
- 间歇性化疗显示出有利的安全性.
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