在出生时体重非常低的婴儿中,随着时间的推移,认知功能的变化
Laura R Ment1, Betty Vohr, Walter Allan
1Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, Conn 06520, USA. laura.ment@yale.edu
JAMA
|February 15, 2003
概括
大多数出生时体重非常低 (VLBW) 的孩子表现出认知能力的改善,在童年期间口语和智商得分都有所提高. 然而,那些患有早期腹腔内出血 (IVH) 和中枢神经系统损伤的人经历了分数的下降.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 认知心理学 认知心理学
背景情况:
- 非常低出生体重 (VLBW) 的婴儿面临神经发育障碍的高风险.
- 新出现的证据表明,在早期受伤后,大脑有潜在的恢复和补偿能力.
研究的目的:
- 调查VLBW早产儿童的认知发展轨迹.
- 评估从早期到中年儿童期的长期认知变化.
主要方法:
- 从随机对照试验中对296名VLBW婴儿的前性随访.
- 36,54,72,96个月的连续认知评估经过年龄校正 (CA).
- 使用的皮博迪图片词汇测试修订 (PPVT-R) 和智商指数 (IQ) 措施.
主要成果:
- 中位数PPVT-R得分从36个月CA时的88个提高到96个月CA时的99个.
- 45%的儿童在PPVT-R上获得了≥10分;12.5%获得了5-9分.
- 较高的母亲教育和双亲家庭与更好的PPVT-R分数相关. 早期干预有利于受教育程度较低的母亲的孩子.
- 患有早期腹腔内出血 (IVH) 和中枢神经系统损伤的儿童最初的得分较低,随后下降.
结论:
- 大多数VLBW儿童随着时间的推移表现出认知能力的改善.
- 主要观察到VLBW婴儿的认知能力下降,这些婴儿患有早期发作的IVH和严重的中枢神经系统损伤.
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