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Updated: Jul 9, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Published on: October 26, 2015

通过结晶诱导的二重选择性转换有效合成NK(1) 受体对手阿普雷皮坦

Karel M J Brands1, Joseph F Payack, Jonathan D Rosen

  • 1Department of Process Research, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

Journal of the American Chemical Society
|February 20, 2003
PubMed
概括

这项研究提出了一种有效的立体选择合成阿普雷皮坦,NK1受体对抗剂. 这种新的方法实现了55%的总产量,为这个重要的候选药物提供了可行的途径.

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