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心肌前炎性细胞因子表达和左心室重塑在患有慢性腹吐的患者
Hakan Oral1, Natarajan Sivasubramanian, David B Dyke
1Division of Cardiology, University of Michigan and Veterans Affairs Medical Centers, Ann Arbor, USA. oralh@umich.edu
Circulation
|February 20, 2003
概括
慢性额头 (MR) 在患者中增加心肌瘤缩因子-α (TNF-α). 中心修复手术减少TNF-alpha,改善左心室重塑,表明TNF-alpha在MR中的作用.
科学领域:
- 心血管生物学 心血管生物学
- 分子医学是分子医学.
- 心脏外科手术 心脏外科手术
背景情况:
- 在动物模型中,伸展会诱导心肌瘤缩因子-α (TNF-α).
- 慢性腹 (MR) 导致左心室 (LV) 体积过载.
- 这项研究研究了MR患者的LV体积过载的TNF-α诱导.
研究的目的:
- 确定MR患者的LV体积过载是否会诱导心肌和全身TNF-α表达.
- 评估TNF-α表达和LV重塑之间的关系.
- 评估中枢 (MV) 修复对TNF-alpha水平和LV重塑的影响.
主要方法:
- 在26名MR患者中测量了血TNF-α和受体,其中26名患者在MV修复前和9名患者在MV修复后.
- 通过RT-PCR对11名MR患者和10名捐赠心脏进行了量化心肌TNF-alphamRNA.
- 与LV体积和重塑参数相关联的心肌TNF-α表达.
主要成果:
- 与对照组相比,MR患者表现出血TNF-α和受体的升高.
- 心肌TNF-alpha mRNA在MR患者中显著高于在供体心脏中.
- MV修复降低了血TNF-α水平和受体.
- 心肌TNF-α与LV体积相关,与术后LV重塑相反.
结论:
- 在MR患者的心肌和血中表达TNF-α.
- 中心手术可以逆转TNF-alpha的表达,并减轻LV体积的过载.
- TNF-α表达与MR中的LV重塑有关,这表明它在病变发生过程中发挥了作用.
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