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相关概念视频

Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Heart Failure II: Pathophysiology

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Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Cardiomyopathy II: Dilated Cardiomyopathy

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Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
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Published on: February 20, 2017

在患有慢性功能衰竭的儿科患者中,左心室质量和缩性能.

Mark M Mitsnefes1, Thomas R Kimball, Sandra A Witt

  • 1Division of Nephrology and Hypertension, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, USA. mark.mitsnefes@CCHMC.org

Circulation
|February 20, 2003
PubMed
概括

患有慢性病的儿童显示左心室质量增加和静止时的收缩性. 然而,透析患者在运动期间表现出减少的收缩储备,这可能预示着未来的缩功能障碍.

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科学领域:

  • 儿童心脏病学 儿童心脏病学
  • 腎臟病學 (nephrology) 是一種醫學.
  • 心血管生理学心血管生理学

背景情况:

  • 患有慢性病的儿童通常会出现左心室缩 (LVH).
  • 假设LVH是对儿科慢性病中增加后负荷和前负荷的适应性反应.
  • 了解 LV 质量,性能和收缩性对于这些脆弱患者至关重要.

研究的目的:

  • 评估左心室 (LV) 质量,LV性能和LV收缩性之间的关联.
  • 为了比较慢性功能不足 (CRI) 的儿童和慢性透析患者的这些参数.
  • 在这些儿科群体中,评估运动期间的收缩储备.

主要方法:

  • 在休息和高峰运动时对25名患有CRI的儿童,12名慢性透析患者和24名对照儿童进行心声学评估.
  • 使用缩短分数和心率校正速度的周围纤维缩短 (VCF) 评估LV性能.
  • 根据VCF,末缩壁应力和运动反应来确定收缩性和收缩性储备.

主要成果:

  • 与对照组相比,CRI和透析组的左心室质量指数 (LVM) 显著更高.
  • 在休息状态下,CRI和透析组显示VCF和收缩性增加,较低的壁面应力.
  • 与对照人群相比,透析患者在运动高峰期间表现出明显较低的收缩储备.

结论:

  • 患有CRI和慢性透析的儿童呈现高LVM,LV性能和休息时的收缩性.
  • 在运动期间透析患者的收缩储备减少可能预测未来的缩功能障碍.
  • 这些发现强调了慢性病和儿童透析对心脏的影响.