接种BCG疫苗和阿托皮的风险
Tyra G Krause1, Anders Hviid, Anders Koch
1Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark. tgv@ssi.dk
JAMA
|February 25, 2003
概括
婴儿BCG疫苗接种似乎没有降低患亚托皮症的风险. 这项研究发现,在接种疫苗和未接种疫苗的儿童之间,亚托皮患病率没有显著差异.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 建议进行Bacille Calmette-Guérin (BCG) 疫苗接种,以预防过敏性疾病.
- 在格陵兰,BCG疫苗接种一直是常规的,直到1990年,它被取消后,就可能增加儿童性亚托皮症的可能性进行了调查.
研究的目的:
- 调查BCG疫苗接种与儿童中阿托皮病的发展之间的联系.
- 为了检查BCG疫苗接种的年龄是否会影响阿托皮风险.
主要方法:
- 在格陵兰,对1686名8岁至16岁的学童进行了横截面研究.
- 对常见的吸入性过敏原的血清IgE水平进行测量,以确定阿托皮症.
- 收集了关于BCG疫苗接种状态和接种时的年龄的数据.
主要成果:
- 在BCG疫苗接种和未接种儿童之间没有观察到亚托皮风险的显著差异 (OR,1.03;95% CI,0.72-1.48).
- 接种BCG疫苗的年龄与发展阿托皮的风险没有关联 (P = .17).
结论:
- 婴儿BCG疫苗接种与阿托皮发育的风险降低无关.
- 这些发现表明,BCG疫苗接种不会在这个人群中提供对亚托皮的保护.
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