干扰因复发性缓解性多发性硬化症中的干扰:系统性审查
Graziella Filippini1, Luca Munari, Barbara Incorvaia
1Unità di Neuroepidemiologia, Istituto Nazionale Neurologico C Besta, Milan, Italy. gfilippini@istituto-besta.it
Lancet (London, England)
|February 25, 2003
概括
再组合干扰素可能会在第一年稍微减少复发性复发性多发性硬化症恶化. 这些多发性硬化治疗的长期有效性和副作用需要在新的临床试验中进一步调查.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 重组干扰素已被批准用于复发性缓解性多发性硬化症 (RRMS).
- 关于它们在RRMS管理中的有效性,益处,副作用和成本,目前仍存在争论.
- 证据综合对于在RRMS治疗中做出明智的临床决策至关重要.
研究的目的:
- 评估复合干扰素在治疗RRMS中的有效性.
- 为了确定与安慰剂相比,复合干扰素是否可以减少临床恶化和疾病进展.
- 评估复合干扰素对类固醇使用和RRMS患者住院的影响.
主要方法:
- 使用Cochrane协作方法的随机,安慰剂对照试验 (1993-2002) 的系统综述.
- 包括1215名RRMS患者接受了复合干扰素治疗.
- 分析了有关恶化,疾病进展,类固醇使用,住院和MRI结果的数据.
主要成果:
- 干扰素在第一年显示出减少恶化的趋势 (RR 0.73).
- 2年后的结果由于放弃和敏感性分析而没有确定性.
- 常见的副作用对患者的生活质量产生了负面影响;关于类固醇使用,住院和MRI结果的数据不足.
结论:
- 再组合干扰素在RRMS治疗的第一年提供略微减少恶化.
- 这些多发性硬化疗法的长期临床有效性仍然不确定.
- 需要进行进一步的试验,以充分评估RRMS中复合干扰素的长期疗效和安全性.
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