血清C-反应蛋白水平与腹腔大动脉动脉瘤大小有关,并且可能由动脉瘤组织产生
Tryfon Vainas1, Tim Lubbers, Frank R M Stassen
1Department of Surgery, University Hospital of Maastricht and Cardiovascular Research Institute of Maastricht, Maastricht, The Netherlands. t.vainas@ah.unimaas.nl
Circulation
|March 5, 2003
概括
高敏感性C反应蛋白 (hsCRP) 水平与腹腔大动脉瘤 (AAA) 大小相关. 在一些患者中,动脉瘤组织可能会产生CRP,突出显示AAA发育中的炎症.
科学领域:
- 心血管医学 心血管医学
- 炎症研究 炎症研究
- 血管生物学 血管生物学
背景情况:
- 腹腔大动脉动脉瘤 (AAA) 呈现出显著的跨壁炎症.
- 反应性C蛋白 (CRP) 是已确定的心血管疾病风险因素.
- 需要进一步研究CRP和AAA维度之间的关系.
研究的目的:
- 为了研究血清CRP水平与无症状AAA患者的动脉瘤直径之间的关联.
- 为了确定动脉瘤组织是否产生CRP.
主要方法:
- 在39名AAA患者中测量了血清高敏感性CRP (hsCRP) 水平.
- 动脉瘤的尺寸被记录下来.
- 在16名患者的动脉瘤组织中评估了CRP信使RNA (mRNA) 的存在.
主要成果:
- 血清hsCRP显示与动脉瘤大小有显著的正相关性 (r=0.477,P=0.002).
- 大动脉直径随着高hsCRP三角形 (49毫米,61毫米,67毫米) 的增加而逐渐增加.
- 在分析的动脉瘤组织的25%中检测到CRPmRNA.
结论:
- 血清hsCRP与AAA患者的动脉瘤大小有关.
- 在动脉瘤组织内局部产生CRP.
- 这些发现支持炎症在AAA病变发生中的作用,并建议hsCRP作为AAA疾病的潜在生物标志物.
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Aneurysm I: Introduction
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Aneurysm III: Interprofessional Care
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...


