口腔健康和外周动脉疾病
Hsin-Chia Hung1, Walter Willett, Anwar Merchant
1Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Circulation
|March 5, 2003
概括
口腔健康不佳,特别是牙脱落和牙周病,与患外围动脉疾病 (PAD) 的风险更高有关. 这种关联在患有牙周问题的男性中尤为强烈,这表明口腔感染-炎症途径.
科学领域:
- 心血管健康 心血管健康
- 口腔医学是指口腔医学.
- 流行病学 流行病学
背景情况:
- 现有的研究将口腔健康不良与心血管疾病 (如心脏病发作和中风) 联系起来.
- 然而,口腔健康与外围动脉疾病 (PAD) 之间的关联仍未得到充分研究.
研究的目的:
- 调查口腔健康的各种指标与外围动脉疾病 (PAD) 的发生率之间的关系.
主要方法:
- 一项前性研究对45136名男性卫生专业人员进行了12年的跟踪,监测心血管健康和口腔状态.
- 与基线和随访口腔健康数据相关的PAD病例被确定并分析.
主要成果:
- 累积的牙损失与患上PAD的风险增加有显著的关联.
- 牙周病史增加了41%,随访期间任何牙损失增加了39%的风险.
- 牙脱落和PAD之间的关联在有牙周病史的男性中明显更强 (RR 1.88) 与没有牙周病史的男性相比 (RR 0.92).
结论:
- 偶发性牙损失是外周动脉疾病 (PAD) 的重要危险因素,特别是在患有牙周病的人群中.
- 这些发现支持口腔感染-炎症途径有助于PAD发展.
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