在学校年龄的婴儿患有支气管肺形和呼吸功能的流量限制
Marco Filippone1, Maddalena Sartor, Franco Zacchello
1Department of Paediatrics, School of Medicine, University of Padova, Via Giustiniani 3, 35128, Padova, Italy.
Lancet (London, England)
|March 7, 2003
概括
患有支气管肺功能障碍 (BPD) 的婴儿可能会有持久的肺功能问题. 婴儿期的早期呼吸评估可以识别患有BPD的儿童在童年期间有不完全恢复的风险.
科学领域:
- 儿科肺病学 儿科肺病学
- 新生儿科学 新生儿科学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 支气管肺功能障碍症 (BPD) 是一种慢性肺部疾病,影响婴儿.
- 虽然许多婴儿康复,但有些人会出现长期的呼吸问题.
- 识别患有持续问题风险的婴儿对于及时干预至关重要.
研究的目的:
- 为了研究中度至重度支气管肺功能不良的儿童的长期肺功能.
- 为了确定早期的肺功能评估是否可以预测这些儿童以后的呼吸结果.
主要方法:
- 对18名被诊断患有中度至重度BPD的儿童进行了一项纵向研究.
- 肺功能测试,包括1秒内强制呼气体积 (FEV1) 和强制中呼吸流量 (FEF25-75),在学龄被评估.
- 功能剩余容量的最大流量 (Vmax(FRC)) 在24个月大时被测量.
主要成果:
- 在18名儿童中,15名 (83%) 在学龄时表现出低于正常的FEV1和FEF25-75值.
- 在24个月后,FEV1和FEF25-75都与Vmax和FRC显著正相关 (r=0.68和0.85,分别).
- 这些发现表明,早期肺功能与晚期结果之间存在联系.
结论:
- 在婴儿期评估呼吸功能对于识别患有BPD的儿童有价值.
- 早期的肺部评估可以帮助预测儿童时期呼吸功能不完全恢复的风险.
- 这些信息可以指导针对高危儿童的有针对性的后续和管理策略.
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