急性心肌梗塞后的抗生素治疗:一项前性随机研究
Ralf Zahn1, Steffen Schneider, Birgit Frilling
1Kardiologie, Herzzentrum Ludwigshafen, Germany. erzahn@aol.com
Circulation
|March 12, 2003
概括
在急性心肌梗塞 (AMI) 患者中,罗西胺治疗并没有降低死亡率或发病率. 这项研究表明,对于AMI患者,不建议常规使用类抗生素.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 克拉米迪亚肺炎感染与动脉样硬化病变发生有关.
- 研究了罗西胺素对急性心肌梗塞 (AMI) 患者的死亡率和发病率的影响.
研究的目的:
- 为了确定罗西胺治疗是否减少急性心肌梗塞后患者的死亡率或发病率.
主要方法:
- 在一项双盲研究中,872名AMI患者每天接受300毫克罗西思罗米或安慰剂,持续6周.
- 主要终点是12个月总死亡率;次要终点包括综合事件率.
- 患者被随机分配,基线特征和治疗方法在各组之间得到了很好的平衡.
主要成果:
- 在12个月的总死亡率相似:6.5%的罗西菌素与6.0%的安慰剂 (P=0.739).
- 罗西胺和安慰剂组之间的二次结合终点没有显著差异.
- 较高比例的患者在罗西胺组中断了研究药物 (18%对11%).
结论:
- 在AMI患者中,罗西胺治疗并没有降低12个月事件率.
- 研究结果不支持在急性心肌梗塞患者中常规使用类抗生素.
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