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Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
国家临床研究企业面临的核心挑战
Nancy S Sung1, William F Crowley, Myron Genel
1Burroughs Wellcome Fund, PO Box 13901, 21 T. W. Alexander Dr, Research Triangle Park, NC 27709, USA. nsung@bwfund.org
JAMA
|March 14, 2003
概括
将科学发现转化为患者的好处面临着重大障碍. 解决公众参与,信息系统,劳动力培训和资金方面的挑战,需要所有利益相关者共同努力,以改善临床研究.
科学领域:
- 临床研究是临床研究.
- 翻译科学是翻译的科学.
- 卫生政策 卫生政策
背景情况:
- 医学科学家和公共卫生官员越来越担心,科学发现不能有效地转化为人类的利益.
- 临床研究圆桌会议 (2000年召开) 强调了临床研究企业面临的问题.
- 临床研究受到高成本,进展缓慢,资金短缺,监管障碍,基础设施碎片化,数据不兼容以及劳动力/参与者短缺的负担.
研究的目的:
- 确定和阐述当前临床研究中的四个核心挑战:公众参与,信息系统,劳动力培训和资金.
- 为应对这些挑战提出建议,并将责任分配给特定的利益相关者.
- 促进更广泛的对话,以提高美国临床研究企业的绩效.
主要方法:
- 该研究通过在临床研究企业中不同利益相关者之间的协作讨论来确定关键挑战.
- 它分析了导致两个主要转化块的因素:基础科学到临床研究,临床研究到医疗实践.
- 根据所确定的挑战和需要多方利益相关者合作,制定建议.
主要成果:
- 两个主要的翻译障碍阻碍了研究成果的有效应用.
- 已经确定了四个核心挑战:公众参与,信息系统,劳动力培训和资金.
- 系统利益相关者之间的协作努力对于克服这些转化障碍至关重要.
结论:
- 消除转化障碍需要一个协调一致的,协作的方法,涉及医疗保健系统的所有利益相关者.
- 解决已确定的挑战对于提高临床研究的效率和影响至关重要.
- 持续的对话和参与性努力对于推动美国临床研究企业的发展至关重要.
关键词:
生物医学和行为研究研究.
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