消除神话 - - 工业合成中的生物催化剂
Hans E Schoemaker1, Daniel Mink, Marcel G Wubbolts
1DSM Research, Life Science Products, Post Office Box 18, 6160 MD Geleen, Netherlands. hans.schoemaker@dsm.com
概括
生物催化剂为工业合成提供了一个可持续的途径,但面临着局限性. 基因组学和酶进化的进步正在扩大其在化学和制药生产中的应用.
科学领域:
- 生物催化和工业生物技术.
背景情况:
- 生物催化剂越来越多地用于合成化学品,药品和食品成分.
- 目前的应用受到诸如酶可用性,基质范围和操作稳定性等因素的限制.
研究的目的:
- 通过最近的科学进展,探索克服生物催化剂局限性的潜力.
- 预测未来生物催化在工业合成中的扩展.
主要方法:
- 利用基因组学中的突破来促进酶的发现.
- 采用定向酶进化来增强生物催化剂的特性.
- 利用生物多样性用于新型生物催化剂的识别.
- 利用代谢通路工程来进行多步合成.
主要成果:
- 最近的进展为生物催化剂的关键局限性提供了解决方案.
- 在各个部门预计将有新的工业应用.
- 扩展包括单阶段的酶转化和复杂的微生物合成.
结论:
- 科学进步有望显著扩大生物催化剂的工业范围.
- 代谢工程和先进的酶技术将推动未来的创新.
- 生物催化剂将成为化学制造中更具多功能性和强大的工具.
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