血小板对运动的反应与冠状动脉血管学发现在患有努力性心痛的患者之间的关系
Gaetano Antonio Lanza1, Alfonso Sestito, Sonia Iacovella
1Istituto di Cardiologia, Università Cattolica del Sacro Cuore, Roma, Italy. g.a.lanza@inwind.it
Circulation
|March 19, 2003
概括
在患有阻塞性冠状动脉疾病 (CAD) 和正常冠状动脉 (NCAs) 的患者中,运动对血小板反应有不同的影响. 运动后关闭时间的变化可以准确地区分这些群体.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 诊断医学 诊断医学
背景情况:
- 在阻塞性冠状动脉疾病 (CAD) 中,血小板反应性随着运动而增加,但在X综合征中并非如此.
- 在心痛患者中,区分阻塞性CAD与正常冠状动脉 (NCAs) 在临床上很重要.
研究的目的:
- 确定运动诱导的血小板活性变化是否能在患有稳定性心痛的患者中区分阻塞性CAD和NCAs.
主要方法:
- 对194名接受冠状动脉血管造影的稳定心痛患者进行前性研究.
- 使用血小板功能分析仪 (PFA) -100系统 (关闭时间) 测量血小板反应性. 运动前后.
- 冠状动脉血管学用于确认CAD或NCA.
主要成果:
- 在NCA患者 (78.0±16s) 和CAD患者 (95.5±23s) 中,基线关闭时间较短.
- 运动减少了CAD患者的关闭时间 (-15.5s),但增加了NCA患者的关闭时间 (+12.5s).
- 关闭时间的变化≥10秒显示了100%的特异性,用于将患者分类为患有NCA或CAD.
结论:
- 运动诱导的血小板活性变化预测了稳定心痛患者的冠状动脉状况.
- 运动后关闭时间增加≥10秒是正常冠状动脉 (NCAs) 的强有力的指标.
- 运动后关闭时间减少≥10秒是阻塞性冠状动脉疾病 (CAD) 的强有力的指标.
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