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相关概念视频

Lewis Structures of Molecular Compounds and Polyatomic Ions02:54

Lewis Structures of Molecular Compounds and Polyatomic Ions

To draw Lewis structures for complicated molecules and molecular ions, it is helpful to follow a step-by-step procedure as outlined:
Acid Strength and Molecular Structure03:05

Acid Strength and Molecular Structure

Binary Acids and Bases
In the absence of any leveling effect, the acid strength of binary compounds of hydrogen with nonmetals (A) increases as the H-A bond strength decreases down a group in the periodic table. For group 17, the order of increasing acidity is HF < HCl < HBr < HI. Likewise, for group 16, the order of increasing acid strength is H2O < H2S < H2Se < H2Te. Across a row in the periodic table, the acid strength of binary hydrogen compounds increases with increasing...
Molecular Structure and Acidity02:34

Molecular Structure and Acidity

An acid can be deprotonated to form a conjugate base or an anion. If the produced anion is more stable, then the acid is stronger. On the contrary, if the anion is unstable, then the acid is weaker. Hence, to determine the acidity of the compound, the stability of its conjugate base is studied using various factors.
The size effect explains the change in atomic size on acidity. When comparing the acids formed from elements that belong to the same column in the periodic table, their atomic sizes...
Structures of Carboxylic Acid Derivatives01:28

Structures of Carboxylic Acid Derivatives

Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
Structure of Amines01:19

Structure of Amines

The hybridized nitrogen atom in amines possesses a lone pair of electrons and is bound to three substituents with a bond angle of around 108°, which is less than the tetrahedral angle of 109.5°. However, the C–N–H bond angle is slightly larger at 112°, with a carbon–nitrogen bond length of 147 pm. This carbon–nitrogen bond length of of amines is longer than the carbon–oxygen bond of alcohols (143 pm) but shorter than alkanes’ carbon–carbon bond (154 pm). These aspects are illustrated in Figure...
Hydrogen Bonds01:04

Hydrogen Bonds

A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...

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Synthesis and Structure Determination of &#181;-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
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Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

氨基和以太化酸试剂-结构和动态.

Hans J Reich1, Wayne S Goldenberg, Aaron W Sanders

  • 1Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA. reich@chem.wisc.edu

Journal of the American Chemical Society
|March 20, 2003
PubMed
概括

在基试剂中的化作用会影响聚合. 以太合物与THF竞争,而氨基合物显示有限的相互作用,导致显著的二分体形成和特定的结构见解.

科学领域:

  • 有机金属化学 有机金属化学
  • 有机合成 有机合成
  • 频谱学是一种光谱学.

背景情况:

  • 乙试剂在有机合成中至关重要.
  • 了解它们的聚合状态是控制反应性的关键.
  • 使用整形替代剂进行化可以显著改变试剂的行为.

研究的目的:

  • 调查胺和以太替代物的合胺和以太替代物的对烯聚合物的影响.
  • 用先进的光谱技术阐明化作用的结构后果.
  • 为了比较不同环形大小和异构原子 (N与O) 的化能力.

主要方法:

  • 可变温度6Li和13C核磁共振 (NMR) 光谱学.
  • 6Li和15N同位素的标记研究.
  • 研究溶剂添加剂的作用,包括四氨酸 (THF) 和1,1,4,7,10-甲基二乙烯胺 (PMDTA).

主要成果:

  • 5环和6环以太酸盐 (化合物4,5) 与THF有效竞争.
  • 六环胺基酸盐 (化合物2) 与THF竞争较弱,而七环胺基酸盐 (化合物3) 与THF没有竞争.
  • 与模型化合物相比,化烯酸试剂表现出显著增强的二分化,因子范围从40到超过20万.

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  • 通过在同位素标记化合物中的NMR合,为2-(2-dimethylaminoethyl) phenyllithium (2) 分配了一个特定的A型二元体结构.
  • 化合物2单体没有可检测的化,而其二元体则表现出化.
  • 2 - 甲基 (甲基) (4) 形成一个开放的二元体和一个五坐标的单元体.
  • 大多数试剂与PMDTA一起形成单体,非化添加物.
  • 结论:

    • 整形替代剂的化强烈促进了烯试剂中的二分化.
    • 替代剂在与THF竞争中比氨基替代剂更有效的化剂.
    • 合二元的特定结构赋值是可能的,为聚合行为提供了洞察力.