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Updated: Jul 9, 2026

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome
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Published on: March 2, 2018

组织素H3素27甲基化在X无活化中的作用

Kathrin Plath1, Jia Fang, Susanna K Mlynarczyk-Evans

  • 1Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.

Science (New York, N.Y.)
|March 22, 2003
PubMed
概括

聚合组 (PcG) 蛋白质Eed和Ezh2复合体在胚胎和胚胎外细胞的X失活启动过程中被招募到不活跃的X染色体 (Xi). 这种由XistRNA调解的招募导致了组分体H3氨酸27甲基化,但不足以使基因沉默.

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