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抑制功能合的环氧基因酶-2/前列腺素E合成酶,作为人类对simvastatin依赖的斑块稳定的基础

Francesco Cipollone1, Maria Fazia, Annalisa Iezzi

  • 1Department of Medicine and Aging, School of Medicine, University of Chieti G. d'Annunzio, Chieti, Italy.

Circulation
|March 26, 2003
PubMed
概括

辛瓦斯塔丁可降低炎症并抑制心血管斑块内的巨细胞中COX-2/mPGES的表达. 这种作用通过减少矩阵金属蛋白酶 (MMP) 诱导的破裂,有助于斑块稳定.

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