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相关概念视频

Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...

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相关实验视频

Updated: Jul 7, 2026

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols
08:31

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols

Published on: October 18, 2016

在接受delta9-tetrahydrocannabinol的人群中,由植物血凝诱导的淋巴细胞转化.

R J Lau, D G Tubergen, M Barr

    Science (New York, N.Y.)
    |May 31, 1976
    PubMed
    概括

    慢性大麻吸烟者在delta-9-THC给药期间没有显著改变淋巴细胞对植物血凝素的反应. 这表明,delta-9-tetrahydrocannabinol (THC) 可能不会抑制健康个体的免疫功能,而有大麻使用史.

    科学领域:

    • 免疫学 免疫学 免疫学
    • 药理学 药理学是指药理学的学科.
    • 对于大麻素的研究

    背景情况:

    • 大麻的使用广泛,其中delta-9-tetrahydrocannabinol (delta9-THC) 是主要的精神活性成分.
    • 长期暴露于delta9-THC对免疫功能的影响,特别是T细胞介导反应,需要进一步阐明.

    研究的目的:

    • 为了研究持续的delta9-THC给药对慢性大麻吸烟者的淋巴细胞增殖的影响.
    • 为了确定以前的大麻使用是否会影响delta9-THC的免疫调节作用.

    主要方法:

    • 八名健康的男性慢性大麻吸烟者参加了一项为期30天的住院研究.
    • 参与者接受了安慰剂,随后18天服用210毫克/天的delta9-THC,然后再次接受安慰剂.
    • 在整个研究期间测量了淋巴细胞对植物血凝素 (PHA) 刺激的反应.

    主要成果:

    • 每天摄入含有210毫克delta9-THC的大麻提取物,持续18天,并没有抑制淋巴细胞对PHA的反应.
    • 长期吸食大麻的历史似乎也没有损害这些特定的免疫反应.

    结论:

    • 持续使用高剂量的delta9-THC并没有抑制慢性大麻使用者的T细胞反应能力.

    更多相关视频

    Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
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    Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

    Published on: February 28, 2025

    Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
    07:51

    Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

    Published on: August 1, 2025

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    Last Updated: Jul 7, 2026

    Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols
    08:31

    Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols

    Published on: October 18, 2016

    Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
    05:13

    Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

    Published on: February 28, 2025

    Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
    07:51

    Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

    Published on: August 1, 2025

  • 这些发现表明,delta9-THC可能对已建立大麻使用模式的人群中淋巴细胞功能没有临床显著的免疫抑制作用.