通过Drosophila Derailed受体进行Wnt介导的轴突引导
Shingo Yoshikawa1, Randall D McKinnon, Michelle Kokel
1Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, PO Box 85800, San Diego, California 92186, USA.
Nature
|March 28, 2003
概括
果菌的轴突可以在前置或后置指导下选择前置或后置指导,由Derailed受体氨酸激酶指导. 这项研究揭示了Derailed作为Wnt5的受体,在神经系统中调解轴突引导和Wnt信号.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 分子生物学分子生物学
背景情况:
- 双边神经系统的特点是神经元穿过中线.
- 德洛索菲拉的轴突通过前部或后部指导管进行导航.
- 脱轨,一个受体氨酸激酶,指导前部委投影.
研究的目的:
- 调查Derailed在委员会选择中的作用.
- 确定控制轴突通道选择的分子机制.
- 确定参与神经元引导的信号通路.
主要方法:
- 利用Drosophila作为一个模型生物.
- 检查了基因表达和蛋白质功能.
- 进行了轴突指导的遗传和分子分析.
主要成果:
- 脱轨阻止了轴突进入后部通道.
- 脱轨的功能是作为分泌信号分子Wnt5.5的受体.
- Wnt5对于指导轴突到前面的指导管至关重要.
结论:
- 通过脱轨受体发送Wnt5信号,对于正确的轴突引导至关重要.
- 揭示了Wnt家族成员在神经元连接中的新角色.
- 突出了Derailed受体在Wnt介导导向事件中的关键功能.
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