慢性右心房拉伸对心房电力改造在患有心房隔膜缺陷的患者的作用
Joseph B Morton1, Prashanthan Sanders, Jitendra K Vohra
1Department of Cardiology, The Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, Australia.
Circulation
|April 1, 2003
概括
前庭隔膜缺陷 (ASD) 导致由于慢性拉伸而导致右前庭 (RA) 的电力重塑. 这种重塑,包括导电延迟,在ASD关闭后仍然存在,可能导致心房失律.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 心脏外科手术 心脏外科手术
背景情况:
- 患有心房隔膜缺陷 (ASD) 的成年人往往在晚年发展出心房失常.
- 慢性右心房 (RA) 拉伸是这种电力改造的疑似原因.
研究的目的:
- 描述慢性RA延伸引起的心房电力改造的模式和持久性,在患有ASD的成年人中.
主要方法:
- 对13名自闭症患者和17名对照人进行了电生理学研究,以测量心房有效耐火期 (AERP),导电时间和鼻节功能.
- 测量包括AERP分散,crista terminalis导电延迟和P波持续时间.
- 在ASD关闭后进行了后续研究.
主要成果:
- 与对照组相比,自闭症患者的低侧面AERP,P波持续时间和较大的crista terminalis导电延迟显著更长.
- 在ASD关闭后,RA体积仍然增加,crista终端导电延迟持续存在.
- 随访时观察到一种变化的AERP趋势.
结论:
- 慢性RA延伸在ASD导致电改造,包括增加RAERP,鼻节功能障碍和crista终端导电延迟.
- 在ASD关闭后,在crista terminalis持续的导电延迟可能会为长期心房失常症的基质做出贡献.
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